Overexpression of c-Ras in hyperplasia and adenomas of the feline thyroid gland: an immunohistochemical analysis of 34 cases
| Autor: | J. I. Merryman, G. Bowers, E. L. Buckles, Nancy Neilsen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adenoma
Male endocrine system Pathology medicine.medical_specialty endocrine system diseases Thyroid Gland 030209 endocrinology & metabolism medicine.disease_cause Cat Diseases Hyperthyroidism Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine medicine Animals Euthyroid Thyroid Neoplasms music music.instrument CATS Hyperplasia General Veterinary business.industry Thyroid Antibodies Monoclonal medicine.disease Genes p53 Follicular hyperplasia Immunohistochemistry Genes bcl-2 Gene Expression Regulation Neoplastic medicine.anatomical_structure Genes ras 030220 oncology & carcinogenesis Cats Female Carcinogenesis business |
| Zdroj: | Veterinary pathology. 36(2) |
| ISSN: | 0300-9858 |
| Popis: | Formalin-fixed, paraffin-embedded thyroid glands from 18 cats diagnosed with hyperthyroidism were evaluated immunohistochemically for overexpression of the products of oncogenes c-ras and bcl2 and the tumor suppressor gene p53. Fourteen thyroid glands from euthyroid cats without histologically detectable thyroid lesions were examined similarly as controls. Results from these investigations showed that all cases of nodular follicular hyperplasia/adenomas stained positively for overexpression of c-Ras protein using a mouse monoclonal anti-human pan-Ras antibody. The most intensely positively staining regions were in luminal cells surrounding abortive follicles. Subjacent thyroid and parathyroid glands from euthyroid cats did not stain immunohistochemically for pan-Ras. There was no detectable staining for either Bcl2 or p53 in any of the cats. These results indicated that overexpression of c-ras was highly associated with areas of nodular follicular hyperplasia/adenomas of feline thyroid glands, and mutations in this oncogene may play a role in the etiopathogenesis of hyperthyroidism in cats. |
| Databáze: | OpenAIRE |
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