The Influence of Adjuvant Radiotherapy and Single Nucleotide Polymorphisms on Circulating Immune Response Cell Numbers and Phenotypes of Patients With Breast Cancer
| Autor: | Sture Löfgren, Levar Shamoun, Lars Erik Rutqvist, Thitiya Luetragoon, Delmy Oliva, Nongnit Laytragoon Lewin, Bengt-Åke Andersson, Freddi Lewin |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Cancer Research Myeloid T-Lymphocytes medicine.medical_treatment Cell Breast Neoplasms Adaptive Immunity Polymorphism Single Nucleotide Leukocyte Count 03 medical and health sciences 0302 clinical medicine Breast cancer Immune system medicine Humans Neoplasm Metastasis Aged Neoplasm Staging Aged 80 and over Immunity Cellular Innate immune system business.industry Cancer General Medicine Immunotherapy Middle Aged medicine.disease Acquired immune system Immunity Innate Phenotype medicine.anatomical_structure Oncology Case-Control Studies 030220 oncology & carcinogenesis Immunology Female Radiotherapy Adjuvant business Biomarkers |
| Zdroj: | Anticancer Research. 39:4957-4963 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim Adjuvant radiotherapy (RT) damages multiple layers of skin, muscle, blood vessels and blood cells that are included within the RT area. Indirect, bystander systemic effects could also develop in cells not directly hit by radiation. Materials and methods Ninety-three female patients recovering from breast cancer surgery and 82 female healthy blood donors were analyzed. For identification of systemic adaptive and innate immune response, rapid and low-cost blood-based biomarkers were assayed. Results Post-operated breast cancer patients had a decreased number of circulating adaptive immune response cells but increased number of circulating immunosuppressive myeloid subpopulations. RT decreased the number of T-cells and platelets without influencing the number of immunosuppressive myeloid subpopulations. Alterations in the number and phenotypes of T-cell subpopulations were associated with SNPs. Conclusion The combination of RT and immunotherapy might provide optimal treatment for cancer patients. |
| Databáze: | OpenAIRE |
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