Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

Autor: Florian Krammer, Peter Palese, Raffael Nachbagauer, Randy A. Albrecht, John K. Rose, Adolfo García-Sastre, Alex B. Ryder, Matthew S. Miller, Rong Hai
Přispěvatelé: Schultz-Cherry, S
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Influenza Virus
viruses
Hemagglutinin Glycoproteins
Influenza Virus
medicine.disease_cause
Virus Replication
Medical and Health Sciences
0302 clinical medicine
Influenza A Virus
H1N1 Subtype
Influenza A virus
Influenza A Virus
2.2 Factors relating to the physical environment
030212 general & internal medicine
Aetiology
Infectious
virus diseases
Biological Sciences
respiratory system
Viral Load
Infectious Diseases
Influenza Vaccines
Pneumonia & Influenza
Infection
Viral load
Hemagglutinin Glycoproteins
Immunology
Hemagglutinin (influenza)
Biology
Microbiology
H5N1 genetic structure
Virus
Viral vector
Vaccine Related
03 medical and health sciences
Disease Transmission
Orthomyxoviridae Infections
Immunity
Biodefense
Virology
Vaccines and Antiviral Agents
medicine
Disease Transmission
Infectious
Animals
H1N1 Subtype
Agricultural and Veterinary Sciences
Animal
Prevention
Ferrets
Influenza
Disease Models
Animal
030104 developmental biology
Emerging Infectious Diseases
Good Health and Well Being
Viral replication
Insect Science
Disease Models
biology.protein
Immunization
Zdroj: Journal of virology, vol 90, iss 6
Popis: We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.
Databáze: OpenAIRE
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