Absence of Chronic Human Immunodeficiency Virus Infection without Seroconversion in Intravenous Drug Users: A Prospective and Retrospective Study
| Autor: | Jean-Jacques Déglon, Sabine Yerly, Eric Chamot, Bernard Hirschel, Luc Perrin |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Immunoblotting HIV Infections HIV Antibodies Polymerase Chain Reaction Virus Cohort Studies Acquired immunodeficiency syndrome (AIDS) DNA Viral/analysis Humans Immunology and Allergy Medicine Prospective Studies Seroconversion Substance Abuse Intravenous Prospective cohort study Retrospective Studies ddc:616 HIV Infections/ diagnosis/etiology biology business.industry Carrier State/ diagnosis virus diseases Retrospective cohort study Substance Abuse Intravenous/ complications Provirus medicine.disease Virology Blotting Southern Infectious Diseases Carrier State DNA Viral Immunology HIV-1 biology.protein Female Viral disease Antibody HIV Antibodies/blood business HIV-1/genetics/immunology/ isolation & purification Follow-Up Studies |
| Zdroj: | The Journal of Infectious Diseases, Vol. 164, No 5 (1991) pp. 965-968 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/164.5.965 |
| Popis: | It has been reported that human immunodeficiency virus type 1 (HIV-1) infection may exist in persons without specific antibodies for years. To measure the frequency of a silent carrier state, a study was conducted in a cohort of 124 intravenous drug users (IVDUs) without anti-HIV-1 antibodies. All the participants had engaged in high-risk behavior for HIV-1 transmission for a number of years until 1987 or later. Samples were analyzed at 6-month intervals for the presence of HIV-1 provirus using DNA amplification and for the appearance of anti-HIV-1 antibodies. HIV-1 provirus and antibodies were undetectable in 122 participants, whereas seroconversion was observed in 2. In one of these, both amplified HIV-1 pol gene segment and anti-HIV-1 antibodies were detected simultaneously, and in the other, provirus was detected 1 month before seroconversion. This study suggests that long-term HIV-1 infection without anti-HIV-1 antibodies is rare and that repeated antibody testing is sufficient to determine the HIV-1 status of a person no longer at high risk for HIV-1 infection. |
| Databáze: | OpenAIRE |
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