Validation of a low-cost, carbon dioxide-based cryoablation system for percutaneous tumor ablation

Autor: Grace Kuroki, Saraswati Sukumar, Serena Thomas, Susan C. Harvey, Guannan Wang, Sean Young, Bailey Surtees, Shivam Rastogi, Yixin Hu, Tara Blair, Nicholas J. Durr, Evelyn McChesney, Clifford R. Weiss, Dara L. Kraitchman, Pascal Acree
Rok vydání: 2019
Předmět:
0301 basic medicine
Atmospheric Science
Swine
medicine.medical_treatment
Cancer Treatment
Pathology and Laboratory Medicine
Cryosurgery
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Breast Tumors
Medicine and Health Sciences
Percutaneous tumor ablation
Mammals
Multidisciplinary
Ultrasound
Eukaryota
Cryoablation
Chemistry
Veterinary Surgery
Oncology
030220 oncology & carcinogenesis
Physical Sciences
Vertebrates
Carbon dioxide
Catheter Ablation
Medicine
Female
Research Article
Veterinary Medicine
medicine.medical_specialty
Science
Rat model
Surgical and Invasive Medical Procedures
Necrosis
Greenhouse Gases
03 medical and health sciences
Signs and Symptoms
Breast cancer
Diagnostic Medicine
In vivo
Breast Cancer
medicine
Animals
Environmental Chemistry
business.industry
Ecology and Environmental Sciences
Chemical Compounds
Organisms
Mammary Neoplasms
Experimental
Biology and Life Sciences
Cancers and Neoplasms
Carbon Dioxide
medicine.disease
Rats
030104 developmental biology
chemistry
Atmospheric Chemistry
Amniotes
Earth Sciences
Veterinary Science
Histopathology
Nuclear medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0207107 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0207107
Popis: Breast cancer rates are rising in low- and middle-income countries (LMICs), yet there is a lack of accessible and cost-effective treatment. As a result, the cancer burden and death rates are highest in LMICs. In an effort to meet this need, our work presents the design and feasibility of a low-cost cryoablation system using widely-available carbon dioxide as the only consumable. This system uses an 8-gauge outer-diameter needle and Joule-Thomson expansion to percutaneously necrose tissue with cryoablation. Bench top experiments characterized temperature dynamics in ultrasound gel demonstrated that isotherms greater than 2 cm were formed. Further, this system was applied to mammary tumors in anin vivorat model and necrosis was verified by histopathology. Finally, freezing capacity under a large heat load was assessed with anin vivoporcine study, where volumes of necrosis greater than 1.5 cm in diameter confirmed by histopathology were induced in a highly perfused liver after two 7-minute freeze cycles. These results demonstrate the feasibility of a carbon-dioxide based cryoablation system for improving solid tumor treatment options in resource-constrained environments.
Databáze: OpenAIRE
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