Pre-B-Cell Acute Lymphoblastic Leukemia in Childhood

Autor:	William M. Crist, Ching-Hon Pui, Andrew J. Carroll
Rok vydání:	1990
Předmět:	Cancer Research business.industry Chromosomal translocation Pre B-cell acute lymphoblastic leukemia Hematology Phenotype Minimal residual disease law.invention Pathogenesis Immunophenotyping Oncology law Immunology Recombinant DNA Medicine business Polymerase chain reaction
Zdroj:	Leukemia & Lymphoma. 3:1-6
ISSN:	1029-2403 1042-8194
Popis:	The pre-B-cell (clgM) phenotype of childhood ALL comprises about one-fifth of newly diagnosed cases. It has a high frequency of chromosomal translocation, and is closely associated with the t(l;19)(q23;p13). The poor treatment outcome and high-risk features previously ascribed to this phenotype appear to be primarily due to the subset of cases with the t(l;19). Early results of at least one study suggest that aggressive treatment may even nullify the adverse prognostic implication of the t(l;19). Finally, molecular analyses of these cases have yielded exciting new information regarding the pathogenesis of pre-B-cell ALL with the t(l;19), and recombinant DNA technology (polymerase chain reaction) is likely to make molecular diagnosis and detection of minimal residual disease possible in the near future.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e25f959dc490fa048c4306d319c496 https://doi.org/10.3109/10428199009050969 Zobrazit plný text záznamu