Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials
| Autor: | Ervin I. Weiss, Yael Houri-Haddad, Dana Kesler-Shvero, Abraham J. Domb, Nurit Beyth, Livnat Atar-Froyman, Anat Sharon, Raphael Pilo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Materials science Biocompatibility Biophysics Biocompatible Materials Bioengineering Microbial Sensitivity Tests Cell Line Biomaterials Mice chemistry.chemical_compound Anti-Infective Agents In vivo Cations Tensile Strength Animals Humans Polyethyleneimine Wound Healing Polyethylenimine Antimicrobial Biocompatible material Bandages In vitro Quaternary Ammonium Compounds chemistry Mechanics of Materials Biofilms Wound dressing Ceramics and Composites Nanoparticles Anti biofilm Biomedical engineering |
| Zdroj: | Biomaterials. 46:141-148 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2014.12.047 |
| Popis: | Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties in vitro and in vivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to in vivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient. |
| Databáze: | OpenAIRE |
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