Prediction of Cardiovascular Events in Patients with Ankylosing Spondylitis and Psoriatic Arthritis: Role of Lipoproteins in a High-risk Population
| Autor: | Terje R. Pedersen, Tore K Kvien, Ingar Holme, David A. DeMicco, Rana Fayyad, Chuan-Chuan Wun, John Betteridge, John C. LaRosa, Anne Grete Semb |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Risk medicine.medical_specialty Lipoproteins Immunology Population Gastroenterology Cohort Studies Psoriatic arthritis chemistry.chemical_compound High-density lipoprotein Rheumatology Internal medicine medicine Humans Immunology and Allergy Spondylitis Ankylosing Risk factor education Aged Proportional Hazards Models education.field_of_study medicine.diagnostic_test business.industry Proportional hazards model Arthritis Psoriatic Hazard ratio Middle Aged medicine.disease Lipids Surgery Cholesterol chemistry Cardiovascular Diseases Female lipids (amino acids peptides and proteins) Lipid profile business Lipoprotein |
| Zdroj: | The Journal of Rheumatology. 39:1433-1440 |
| ISSN: | 1499-2752 0315-162X |
| Popis: | Objective.To evaluate lipids and apolipoproteins as predictors of cardiovascular mortality and morbidity (CVD) in patients with spondyloarthritis (SpA).Methods.In the pooled cohort of participants in the IDEAL, TNT, and CARDS trials, 50 had ankylosing spondylitis (AS), 36 had psoriatic arthritis (PsA), and 21,641 did not have AS or PsA (non-SpA). We compared lipid levels at baseline between AS or PsA and non-SpA, and hazard ratios (HR) for CVD were calculated in a Cox proportional hazard model.Results.Atherogenic lipids were lower in samples from AS, but not in PsA, compared to non-SpA. The HR for 1 SD increase in baseline lipids for future CVD was for total cholesterol 1.39 (95% CI 0.82, 2.36) in AS, 1.01 (95% CI 0.44, 2.31) in PsA, and 1.10 (95% CI 1.07, 1.14) in non-SpA. Both high-density lipoprotein (HDL) and apolipoprotein (ApoA-1) were significantly associated with CVD in AS (HR 3.67, 95% CI 1.47, 9.06, and HR 1.89, 95% CI 1.02, 3.54, respectively), in contrast to PsA (HDL: HR 1.03, 95% CI 0.49, 2.15; ApoA-1: HR 0.79, 95% CI 0.34, 1.89) and non-SpA (HDL: HR 0.86, 95% CI 0.84, 0.89; ApoA-1: HR 0.88, 95% CI 0.85, 0.91).Conclusion.HDL and ApoA-1 were surprisingly associated with increased risk of future CVD in patients with AS, whereas these lipids were protective in non-SpA. |
| Databáze: | OpenAIRE |
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