Altered expression of regulatory T and Th17 cells in murine bronchial asthma
| Autor: | Wentao Zheng, Wenxia Wang, Jianbo Zhu, Xiuhe Ouyang, Qingyuan Wang, Xiaoying Liu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research chemical and pharmacologic phenomena Inflammation airway inflammation Biology regulatory T cells Pathogenesis 03 medical and health sciences Immune system Immunology and Microbiology (miscellaneous) RAR-related orphan receptor gamma medicine IL-2 receptor Th17 cells Dexamethasone Asthma FOXP3 hemic and immune systems Articles General Medicine medicine.disease respiratory tract diseases 030104 developmental biology Immunology bronchial asthma medicine.symptom medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Alteration of the careful balance of the ratio of Th1/Th2 cell subsets impacts immune function and plays an important role in the pathogenesis of asthma. There is little research on the impact of changes on the balance of the regulatory T (Treg)/Th17 subset ratio and its possible repercussions for asthma. This investigation used a murine model of asthma to measure the expression levels of Treg and Th17 cells and the levels of their transcription factors Foxp3 and retinoic acid receptor-related orphan nuclear receptor (ROR)γt in bronchial asthma while assessing indexes of airway inflammation. Thirty female SPF BALB/c mice were divided into three equally numbered groups: a normal control, an asthma and a dexamethasone treatment group. All the airway inflammation indexes measured were more prominent in the asthma group and less so in the control group. The percentage of the lymphocyte subset CD4+CD25+Foxp3+ cells in the CD4+ cells in the asthma group was significantly lower than that in the normal control group (P |
| Databáze: | OpenAIRE |
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