Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson’s disease
| Autor: | Candace H. Carriere, Na Hyea Kang, Lennard P. Niles |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Parkinson's disease Nigrostriatal pathway Substantia nigra Striatum Antioxidants Rats Sprague-Dawley Melatonin Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Parkinsonian Disorders Dopamine Rotenone Internal medicine medicine Animals Molecular Biology Tyrosine hydroxylase Uncoupling Agents business.industry General Neuroscience medicine.disease Immunohistochemistry Corpus Striatum Rats 3. Good health Substantia Nigra Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology nervous system chemistry Neurology (clinical) business 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1633:115-125 |
| ISSN: | 0006-8993 |
| Popis: | Parkinson's disease is a major neurodegenerative disorder which primarily involves the loss of dopaminergic neurons in the substantia nigra and related projections in the striatum. The pesticide/neurotoxin, rotenone, has been shown to cause systemic inhibition of mitochondrial complex I activity in nigral dopaminergic neurons, with consequent degeneration of the nigrostriatal pathway, as observed in Parkinson's disease. A novel intrastriatal rotenone model of Parkinson's disease was used to examine the neuroprotective effects of chronic low-dose treatment with the antioxidant indoleamine, melatonin, which can upregulate neurotrophic factors and other protective proteins in the brain. Sham or lesioned rats were treated with either vehicle (0.04% ethanol in drinking water) or melatonin at a dose of 4 µg/mL in drinking water. The right striatum was lesioned by stereotactic injection of rotenone at three sites (4 μg/site) along its rostrocaudal axis. Apomorphine administration to lesioned animals resulted in a significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect