Relationship Between Clinical Control, Respiratory Symptoms and Quality of Life for Patients with COPD

Autor: Alcazar-Navarrete, Bernardino, Fuster, Antonia, García Sidro, Patricia, García Rivero, Juan Luis, Abascal-Bolado, Beatriz, Pallarés-Sanmartín, Abel, Márquez, Eduardo, Valido-Morales, Agustin, Boldova Loscertales, Ana, Callejas-Gonzalez, Francisco Javier, Palop, Marta, Riesco, Juan Antonio, Golpe, Rafael, Soler-Cataluña, Juan Jose, Miravitlles, Marc
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Chronic Obstructive Pulmonary Disease
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
Fundación Universitaria San Pablo CEU (FUSPCEU)
International Journal of COPD, Vol Volume 15, Pp 2683-2693 (2020)
ISSN: 1178-2005
1176-9106
Popis: Background: The concept of clinical control has been proposed as an instrument for evaluating patients with COPD. However, the possible association between clinical control, reduced symptom severity and HRQoL has yet to be confirmed. Methods: This multicentre, prospective and observational study was carried out in 15 pulmonology clinics in Spain. The patients were followed up for six months, with a baseline visit (V0), followed by visits at three months (V1) and six months (V2). Clinical control was determined at V1, with the application of both clinical criteria and the COPD assessment test (CAT). All patients reported their symptoms by a validated symptom diary (E-RS) using a portable device, and their HRQoL was assessed using the EQ5D questionnaire. The relationship between clinical control and E-RS and HRQoL during follow-up was assessed with t-test. Results: A total of 126 patients were screened. After application of the inclusion/exclusion criteria, 93 were finally included (mean age 66 +/- 8 years, 84.9% male), with a mean FEV1 predicted of 49.8% +/- 16.5%. Of these patients, 44 (47.3%) achieved clinical control at V1, according to CAT criteria, and 50 (53.8%), according to clinical criteria. The E-RS scores differed between controlled and uncontrolled patients at all time points, both according to CAT (mean differences of -4.6, -5.6 and -6.2 units at V0, V1 and V2, respectively, p
This study was funded by an unrestricted grant from Novartis Spain. This company did not intervene in the development of the study, data collection, analysis of results or drafting of the manuscript.
Databáze: OpenAIRE
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