Effectiveness of Monovalent and Pentavalent Rotavirus Vaccine
| Autor: | Jacqueline E. Tate, Trisha Chan, Melissa Held, Carol Barrett, Osbourne Quaye, Slavica Mijatovic-Rustempasic, Shabnam Jain, Umesh D. Parashar, Lilly Cheng Immergluck, Rashi Gautam, Saadia Khizer, Jessica Moore, Michael D. Bowen, Marietta Vázquez, Margaret M. Cortese, Alexandra P. Grizas |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Georgia Immunization Secondary medicine.disease_cause Vaccines Attenuated Article Rotavirus Infections Pentavalent vaccine Patient Admission Rotavirus medicine Confidence Intervals Humans business.industry Case-control study Rotavirus Vaccines Infant Emergency department Hospitals Pediatric Rotavirus vaccine Confidence interval Diarrhea Treatment Outcome Immunization Case-Control Studies Pediatrics Perinatology and Child Health Diarrhea Infantile Utilization Review Female medicine.symptom business Emergency Service Hospital |
| Popis: | OBJECTIVE: Previous US evaluations have not assessed monovalent rotavirus vaccine (RV1, a G1P[8] human rotavirus strain) effectiveness, because of its later introduction (2008). Using case-control methodology, we measured the vaccine effectiveness (VE) of the 2-dose RV1 and 3-dose pentavalent vaccine (RV5) series against rotavirus disease resulting in hospital emergency department or inpatient care. METHODS: Children were eligible for enrollment if they presented to 1 of 5 hospitals (3 in Georgia, 2 in Connecticut) with diarrhea of ≤10 days’ duration during January through June 2010 or 2011, and were born after RV1 introduction. Stools were collected; immunization records were obtained from providers and state electronic immunization information system (IIS). Case-subjects (children testing rotavirus antigen-positive) were compared with 2 control groups: children testing rotavirus negative and children selected from IIS. RESULTS: Overall, 165 rotavirus-case subjects and 428 rotavirus-negative controls were enrolled. Using the rotavirus-negative controls, RV1 VE was 91% (95% confidence interval [CI] 80 to 95) and RV5 VE was 92% (CI 75 to 97) among children aged ≥8 months. The RV1 VE against G2P[4] disease was high (94%, CI 78 to 98), as was that against G1P[8] disease (89%, CI 70 to 96). RV1 effectiveness was sustained among children aged 12 through 23 months (VE 91%; CI 75 to 96). VE point estimates using IIS controls were similar to those using rotavirus-negative controls. CONCLUSIONS: RV1 and RV5 were both highly effective against severe rotavirus disease. RV1 conferred sustained protection during the first 2 years of life and demonstrated high effectiveness against G2P[4] (heterotypic) disease. |
| Databáze: | OpenAIRE |
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