Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity
| Autor: | Alik S. Widge, Darin D. Dougherty, Lauren M. Ostrowski, Ziv Williams, Angelique C. Paulk, Emad N. Eskandar, Britni Crocker, Sydney S. Cash, Catherine J. Chu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Drug Resistant Epilepsy Computer science Cognitive Neuroscience Direct electrical stimulation Neurosciences. Biological psychiatry. Neuropsychiatry Stimulation Electroencephalography 050105 experimental psychology Stereoelectroencephalography Correlation 03 medical and health sciences 0302 clinical medicine medicine Connectome Humans 0501 psychology and cognitive sciences sEEG Evoked potential Evoked Potentials Cerebral Cortex Connectivity Resting state fMRI medicine.diagnostic_test 05 social sciences Human brain Intracranial Electric Stimulation medicine.anatomical_structure Diffusion Tensor Imaging Implantable Neurostimulators Neurology Electrocorticography Nerve Net Neuroscience 030217 neurology & neurosurgery RC321-571 Diffusion MRI |
| Zdroj: | NeuroImage, Vol 237, Iss, Pp 118094-(2021) |
| ISSN: | 1095-9572 |
| Popis: | Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including the use of external probing stimuli, such as direct electrical stimulation. To examine how different measures of connectivity correlate with one another, we compared ‘passive’ measures of connectivity during resting state conditions to the more ‘active’ probing measures of connectivity with single pulse electrical stimulation (SPES). We measured the network engagement and spread of the cortico-cortico evoked potential (CCEP) induced by SPES at 53 out of 104 total sites across the brain, including cortical and subcortical regions, in patients with intractable epilepsy (N=11) who were undergoing intracranial recordings as a part of their clinical care for identifying seizure onset zones. We compared the CCEP network to functional, effective, and structural measures of connectivity during a resting state in each patient. Functional and effective connectivity measures included correlation or Granger causality measures applied to stereoEEG (sEEGs) recordings. Structural connectivity was derived from diffusion tensor imaging (DTI) acquired before intracranial electrode implant and monitoring (N=8). The CCEP network was most similar to the resting state voltage correlation network in channels near to the stimulation location. In contrast, the distant CCEP network was most similar to the DTI network. Other connectivity measures were not as similar to the CCEP network. These results demonstrate that different connectivity measures, including those derived from active stimulation-based probing, measure different, complementary aspects of regional interrelationships in the brain. |
| Databáze: | OpenAIRE |
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