Reinforced Hybrid Collagen Sponges for Tissue Engineering
| Autor: | V. N. Bagratashvili, Istranov Leonid P, N. N. Vorob’eva, E. V. Istranova, S. V. Kostyuk, D. S. Dudova, A. G. Grosheva, Boris Shavkuta, Yu. V. Gerasimov, Petr Timashev, Nikita V. Minaev, R. K. Chailakhyan, Tatiana M. Zharikova, K. N. Bardakova, Ekaterina A. Grebenik |
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| Rok vydání: | 2018 |
| Předmět: |
Polyesters
Modulus 02 engineering and technology 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology Mice Tissue engineering Cell Adhesion Animals Humans Cell adhesion Cytotoxicity Cells Cultured Cell Proliferation Tissue Engineering Tissue Scaffolds Chemistry Cell growth General Medicine Biodegradation 021001 nanoscience & nanotechnology 0104 chemical sciences Photopolymer Collagen sponge Biophysics Collagen 0210 nano-technology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:142-147 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4116-8 |
| Popis: | We created an anisotropic material based on collagen sponge and reactive polylactide structured by laser photopolymerization. The combination of collagen with reactive polylactide improves the resistance of the formed matrices to biodegradation in comparison with collagen sponge, while the existence of sites with different mechanical characteristics and cell affinity on the matrix provides directed cell growth during their culturing. It was shown that reinforcement of the collagen sponges 7-fold increased the mean Young's modulus for the hybrid matrix without affecting its cytotoxicity. The developed matrix provides cell adhesion and proliferation along reinforcement lines and can be used for fabrication of tissue engineering constructs. |
| Databáze: | OpenAIRE |
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