Pharmacogenetic research activity in Central America and the Caribbean: a systematic review
| Autor: | María de los A Campos, Jorge Duconge, M.E.G. Naranjo, Carolina Céspedes-Garro, Hilda Roblejo, Lazara K Montané-Jaime, Humberto Fariñas, Eva M Peñas-Lledó, Ronald Ramírez, Carmen I. Villagrán, Fernanda Rodrigues-Soares, Víctor Serrano, Adrián LLerena |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Biomedical Research Pharmacology 03 medical and health sciences 0302 clinical medicine Caribbean region Healthy volunteers Genetics Humans Medicine Scientific activity HLA-A Antigens business.industry Central America Drug metabolizing enzymes 030104 developmental biology Caribbean Region Cytochrome P-450 CYP2D6 HLA-B Antigens Pharmacogenetics Therapeutic Area 030220 oncology & carcinogenesis Family medicine Pharmacogenomics Molecular Medicine Central american Systematic Review business |
| Zdroj: | Pharmacogenomics. 17:1707-1724 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs-2016-0053 |
| Popis: | Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in Central America and the Caribbean. Materials & methods: A literature search for pharmacogenetic studies in each country of the region was conducted on three databases using a list of the most relevant pharmacogenetic biomarkers including ‘phenotyping probe drugs’ for major drug metabolizing enzymes. The review included 132 papers involving 47 biomarkers and 35,079 subjects (11,129 healthy volunteers and 23,950 patients). Results: The country with the most intensive pharmacogenetic research was Costa Rica. The most studied medical therapeutic area was oncology, and the most investigated biomarkers were CYP2D6 and HLA-A/B. Conclusion: Research activity on pharmacogenetics in Central American and the Caribbean populations is limited or absent. Therefore, strategies to promote effective collaborations, and foster interregional initiatives and research efforts among countries from the region could help for the rational clinical implementation of pharmacogenetics and personalized medicine. |
| Databáze: | OpenAIRE |
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