Effects of Combination of Thiazolidinediones with Melatonin in Dexamethasone-induced Insulin Resistance in Mice
| Autor: | S P Gandhi, Prasad Dandawate, Yogesh Suresh Ahire, M Mule, Mahesh M. Ghaisas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
business.industry Glucose uptake Glutathione reductase Pharmaceutical Science Insulin resistance melatonin Type 2 diabetes medicine.disease Melatonin Endocrinology Internal medicine medicine type 2 diabetes Rosiglitazone business Pioglitazone thiazolidinediones Dexamethasone medicine.drug Research Paper |
| Zdroj: | Indian Journal of Pharmaceutical Sciences |
| ISSN: | 1998-3743 0250-474X |
| Popis: | In type 2 Diabetes, oxidative stress plays an important role in development and aggregation of insulin resistance. In the present study, long term administration of the dexamethasone led to the development of insulin resistance in mice. The effect of thiazolidinediones pioglitazone and rosiglitazone, with melatonin on dexamethasone-induced insulin resistance was evaluated in mice. Insulin resistant mice were treated with combination of pioglitazone (10 mg/kg/day, p.o.) or rosiglitazone (5 mg/kg/day, p.o.) with melatonin 10 mg/kg/day p.o. from day 7 to day 22. In the biochemical parameters, the serum glucose, triglyceride levels were significantly lowered (P |
| Databáze: | OpenAIRE |
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