Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR
| Autor: | Ichio Shimada, Shunsuke Imai, Yuji Tokunaga, Takumi Ueda, Koh Takeuchi, Yutaka Kofuku, Yuki Toyama, Yutaro Shiraishi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
Process Chemistry and Technology Chemical technology Resolution (electron density) Dynamics (mechanics) Filtration and Separation TP1-1185 Review dynamics NMR Membrane Chemical engineering GPCR Membrane protein transporter ion channel Biophysics Chemical Engineering (miscellaneous) TP155-156 membrane protein Ion channel Function (biology) G protein-coupled receptor |
| Zdroj: | Membranes Membranes, Vol 11, Iss 604, p 604 (2021) |
| ISSN: | 2077-0375 |
| Popis: | A primary biological function of multi-spanning membrane proteins is to transfer information and/or materials through a membrane by changing their conformations. Therefore, particular dynamics of the membrane proteins are tightly associated with their function. The semi-atomic resolution dynamics information revealed by NMR is able to discriminate function-related dynamics from random fluctuations. This review will discuss several studies in which quantitative dynamics information by solution NMR has contributed to revealing the structural basis of the function of multi-spanning membrane proteins, such as ion channels, GPCRs, and transporters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |