Cellular response to DNA damage. Link between p53 and DNA-PK
| Autor: | Isabelle Salles-Passador, Arun Fotedar, Rati Fotedara |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
DNA damage
Cells DNA-Activated Protein Kinase Biology Protein Serine-Threonine Kinases General Biochemistry Genetics and Molecular Biology Ionizing radiation chemistry.chemical_compound Ataxia Telangiectasia Animals Humans Protein kinase A DNA-PKcs Ecology Cell growth Kinase Nuclear Proteins Genes p53 Cell biology Protein Structure Tertiary DNA-Binding Proteins Biochemistry chemistry Protein kinase domain Oligopeptides DNA DNA Damage |
| Zdroj: | Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 322(2-3) |
| ISSN: | 0764-4469 |
| Popis: | Cells which lack DNA-activated protein kinase (DNA-PK are very susceptible to ionizing radiation and display an inability to repair double-strand DNA breaks. DNA-PK is a member of a protein kinase family that includes ATR and ATM which have strong homology in their carboxy-terminal kinase domain with PI-3 kinase. ATM has been proposed to act upstream of p53 in cellular response to ionizing radiation. DNA-PK may similarly interact with p53 in cellular growth control and in mediation of the response to ionizing radiation. |
| Databáze: | OpenAIRE |
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