Pregnancy-induced increased heart rate is independent of thyroid hormones
| Autor: | Céline Fiset, Sophie Mathieu, Valérie Long |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Mouse Increased heart rate Heart rate Experimental Pregnancy Internal medicine medicine Diseases of the circulatory (Cardiovascular) system Triiodothyronine Cardiac electrophysiology business.industry Thyroid medicine.disease Endocrinology medicine.anatomical_structure Propylthiouracil RC666-701 Cardiology and Cardiovascular Medicine business Hormone medicine.drug |
| Zdroj: | Heart Rhythm O2 Heart Rhythm O2, Vol 2, Iss 2, Pp 168-173 (2021) |
| ISSN: | 2666-5018 |
| Popis: | Background The heart rate increases by 10–20 beats per minute (bpm) throughout pregnancy in women, reaching maximum heart rate in the third trimester. During pregnancy, important changes in thyroid hormones also occur, with increases of up to 50% in the levels of triiodothyronine (T3), the biological active thyroid hormone. In addition, T3 has been shown to regulate cardiac electrophysiology. Objective Thus, in the present study the potential contribution of T3 in pregnancy-induced increased heart rate was explored. Methods We compared the heart rate between nonpregnant and pregnant mice under control conditions and after altering thyroid hormone levels with T3 and propylthiouracil (PTU, an antithyroid drug) treatments. Results Consistent with the clinical data, we found a 58% rise in T3 levels during pregnancy in mice. Although pregnant mice had a higher baseline heart rate (607 ± 8 bpm, P = .004) and higher T3 levels (1.9 ± 0.4 nM, P = .0005) than nonpregnant mice (heart rate: 546 ± 16 bpm; T3 levels: 1.2 ± 0.1 nM), their heart rate responded similarly to T3 treatment as nonpregnant mice (nonpregnant: Δ130 ± 22 bpm; pregnant: Δ126 ± 17 bpm, P = .858). Additionally, the heart rate remained significantly elevated (607 ± 11 bpm, P = .038) and comparable to untreated pregnant mice, after the use of the antithyroid drug PTU, although T3 levels (1.3 ± 0.2 nM, P = .559) returned to nonpregnant values. Conclusion Based on these results, it is unlikely that T3 contributes significantly to the pregnancy-induced increased heart rate. |
| Databáze: | OpenAIRE |
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