Suprahypophyseal Hypogonadism and Hypothyroidism During Prolonged Coma After Head Trauma
| Autor: | John F. Raggio, Michael Kutner, Daniel Rudman, Alan S. Fleischer |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyrotropin Biochemistry Head trauma chemistry.chemical_compound Endocrinology Cerebrospinal fluid Internal medicine Cyclic AMP Craniocerebral Trauma Humans Medicine Testosterone Cyclic adenosine monophosphate Coma Thyrotropin-Releasing Hormone business.industry Biochemistry (medical) Luteinizing Hormone Middle Aged Thyroxine medicine.anatomical_structure chemistry Ventricle Hypothalamus Anesthesia Gonadotropins Pituitary Triiodothyronine Follicle Stimulating Hormone medicine.symptom business Pituitary Hormone-Releasing Hormones Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 45:747-754 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-45-4-747 |
| Popis: | Prolonged coma after head trauma is associated with a depletion of 3′,5′ cyclic adenosine monophosphate (cAMP) in the cerebrospinal fluid (CSF). Because cAMP has been implicated in neuroendocrine secretion, we have examined pituitary-hypothalamic function in 7 adult male patients with traumatic coma lasting longer than 2 weeks. Within 1–3 days after trauma, a ventricular catheter connected to a subcutaneous Rickham reservoir was placed in the lateral ventricle to treat intracranial hypertension. Via the reservoir, CSF cAMP was measured at 2–4 day intervals for 10–25 days. Simultaneously, plasma hormone concentrations were also determined. CSF cAMP and plasma levels of TSH, T4, free T4, T3, LH, FSH, and testosterone became subnormal in all 7 cases. In 5 patients whose level of consciousness fluctuated, the reductions in plasma T4 and testosterone were proportional to both severity of coma (r > 0.89, P 0.81, P < .05). In 3 patients who remained deeply comatose for 17–25... |
| Databáze: | OpenAIRE |
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