Group B Streptococcus Late-Onset Disease: 2003–2010
| Autor: | Berardi A, Rossi C, Lugli L, Creti R, LANARI, MARCELLO, Memo L, Pedna MF, Venturelli C, Ciccia M, Piepoli M, Contiero R, Ferrari F, GBS Prevention Working Group Emilia Romagna, BACCHI REGGIANI, MARIA LETIZIA, PERRONE, ENRICA, TRIDAPALLI, ELISABETTA |
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| Přispěvatelé: | Berardi A, Rossi C, Lugli L, Creti R, Bacchi Reggiani ML, Lanari M, Memo L, Pedna MF, Venturelli C, Perrone E, Ciccia M, Tridapalli E, Piepoli M, Contiero R, Ferrari F, GBS Prevention Working Group Emilia-Romagna |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics Diseases Infant Premature Diseases Group B Cohort Studies 0302 clinical medicine Pregnancy Risk Factors STREPTOCOCCUS Medicine Prospective Studies 030212 general & internal medicine Group B streptococcus Infant Intrapartum chemoprophylaxis Late-onset disease Sepsis Age of Onset Antibiotic Prophylaxis Carrier State Community-Acquired Infections Cross Infection Cross-Sectional Studies Female Humans Incidence Infant Newborn Italy Milk Human Rectum Streptococcal Infections Vagina Streptococcus agalactiae Pediatrics Perinatology and Child Health Arts and Humanities (miscellaneous) Prospective cohort study education.field_of_study Incidence (epidemiology) Perinatology and Child Health 3. Good health Milk Meningitis Human medicine.medical_specialty Population 03 medical and health sciences 030225 pediatrics education Premature SEPSIS business.industry Intrapartum chemoprophylaxi Odds ratio Newborn medicine.disease Mastitis business |
| Zdroj: | PEDIATRICS; Vol 131 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | BACKGROUND:There is insufficient population-based data on group B streptococcus (GBS) late-onset disease (LOD). Risk factors and routes of GBS transmission are poorly understood.METHODS:A prospective, cohort study was conducted to collect incidence data on LOD and evaluate GBS infections over an 8-year period (2003–2010). Starting from January 2007, maternal rectovaginal and breast milk cultures were routinely collected on confirmation of the LOD diagnosis to assess maternal GBS culture status.RESULTS:The incidence rate of LOD was 0.32 per 1000 live births (1.4 and 0.24 per 1000 live births for preterm and term newborns, respectively). The registered cases of LOD (n = 100) were classified as sepsis (n = 57), meningitis (n = 36), or focal infection (n = 7). Thirty neonates were preterm (2 had recurrent infection); 68 were term. Four infants died (3 early preterm, 1 term). At the time the LOD diagnosis was confirmed, 3 (6%) of 53 mothers had GBS mastitis, and 30 (64%) of 47 carried GBS at the rectovaginal site. Early (7–30 days) LOD presentation was associated with neonatal brain lesions or death (odds ratio: 0.96 [95% confidence interval: 0.93–0.99]). Intrapartum antibiotic exposure was significantly associated with mild (12 of 22) rather than severe (11 of 45; P = .03) LOD.CONCLUSIONS:Preterm neonates had the highest rates of LOD and mortality. Most mothers carried GBS at the time of the LOD diagnosis, whereas 6% had mastitis. Intrapartum antibiotics were associated both with delayed presentation of symptoms and milder LOD. |
| Databáze: | OpenAIRE |
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