Aortic root replacement with a novel decellularized cryopreserved aortic homograft: Postoperative immunoreactivity and early results
| Autor: | Kenton J. Zehr, Hartzell V. Schaff, Susan M. Nelson, Heidi M. Connolly, Marineh Yagubyan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Thorax Aortic valve Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Cryopreservation Organ transplantation Aortic aneurysm medicine.artery medicine Humans Aged Aged 80 and over Aorta Decellularization business.industry Panel reactive antibody Middle Aged medicine.disease Surgery surgical procedures operative medicine.anatomical_structure Aortic Valve cardiovascular system Female business Cardiology and Cardiovascular Medicine Vascular Surgical Procedures |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 130(4):1010-1015 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/j.jtcvs.2005.03.044 |
| Popis: | ObjectiveNovel antigen-reduction SynerGraft technology (CryoLife Inc, Kennesaw, Ga) reduces the cellular components of a cadaver homograft with an enzymatic and washing process, leaving the extracellular matrix intact. We report the immunoreactivity (positive panel reactive antibody assay) and early operative results of the CryoLife SynerGraft aortic valve conduit homograft.MethodsTwenty-two patients (age 53 ± 14 years, range 31-80 years) from April 2002 to July 2003 underwent aortic root replacement with a CryoLife SynerGraft aortic valve conduit homograft (CryoLife Inc, Kennesaw, Ga) for congenital or acquired aortic valve disease, aortic aneurysm with aortic valve disease, or native or prosthetic aortic valve endocarditis. Baseline percentage positive panel reactive antibody results were negative ( |
| Databáze: | OpenAIRE |
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