Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term
| Autor: | Lynette B. MacKay, Cordula Fittkow, Holger Maul, Elizabeth Martin, Robert E. Garfield, George R. Saade, Gayle Olson |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent Light Administration Topical medicine.medical_treatment Prostaglandin Cervix Uteri Dinoprostone Fluorescence Andrology symbols.namesake chemistry.chemical_compound Pregnancy medicine Humans Labor Induced Diagnostic Techniques Obstetrical and Gynecological Cervix Misoprostol reproductive and urinary physiology Fisher's exact test Gynecology business.industry Obstetrics and Gynecology medicine.anatomical_structure Reproductive Medicine Eicosanoid chemistry Labor induction embryonic structures Prostaglandins symbols Light induced Female Collagen business hormones hormone substitutes and hormone antagonists Cervical Ripening medicine.drug |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 123:62-66 |
| ISSN: | 0301-2115 |
| Popis: | Objective To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score. Study design The characteristic LIF of cervical collagen was measured from the surface of the cervix using a specially designed instrument (collascope) in 41 gravidas undergoing labor induction at term by prostaglandins. LIF and Bishop-Score were obtained directly before and 4 h after the administration of prostaglandin. Paired Student's t -test, Wilcoxon Signed Rank test, Linear Regression, Spearman correlation and Fisher Exact test were used as appropriate. Results Cervical LIF decreased significantly after prostaglandin application (0.982 ± 0.04 [before] to 0.885 ± 0.037 [after], p = 0.025). The decrease in LIF correlated with the initial LIF before PG-application ( r = 0.61). The Bishop-Score increased in all 41 patients. No correlation was found between LIF versus Bishop-Score. Conclusions Cervical application of prostaglandins decreases the amount of cross-linked collagen as measured by LIF. This effect was observed only in patients with a prior high cross-linked collagen. |
| Databáze: | OpenAIRE |
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