Allopurinol administered prior to hepatic ischaemia in the rat prevents chemiluminescence following restoration of circulation
| Autor: | Peter J. Cohen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty Free Radicals Allopurinol Radical Ischemia Administration Oral Pharmacology law.invention law medicine Animals Rats Wistar Free Radical Formation Chemiluminescence business.industry Vascular disease General Medicine medicine.disease Rats Oxygen Organ damage Anesthesiology and Pain Medicine Liver Reperfusion Injury Anesthesia Luminescent Measurements Light emission Lipid Peroxidation business Liver Circulation medicine.drug |
| Zdroj: | Canadian Journal of Anaesthesia. 39:1090-1093 |
| ISSN: | 1496-8975 0832-610X |
| DOI: | 10.1007/bf03008379 |
| Popis: | Oxygen-derived free radicals produced during reperfusion may be responsible for the disturbed pathology which follows prolonged ischaemia. Measurement of hepatic chemilumine-scence (low level light emission resulting from the energy released during chemical reactions of free radicals) allowed determination of whether allopurinol could prevent formation of oxygen-derived free radicals during reperfusion of the ischaemic liver. While control animals demonstrated a burst of light emission shortly after reperfusion, the rats pretreated with allupurinol showed no evidence of chemiluminescence during either ischaemia or reperfusion. It is concluded that allopurinol may modify reperfusion-induced free radical formation and possibly ameliorate the organ damage which can follow ischaemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink