Bone Marrow Harvest in Pediatric Sibling Donors: Role of Granulocyte Colony-Stimulating Factor Priming and CD34+ Cell Dose
| Autor: | Prakash Satwani, Courtney Briamonte, Monica Bhatia, Aimee Furey, Diane George, Zhezhen Jin, Justine M. Kahn, Yvette C. Tanhehco, Elana Smilow, Remi Prince, Nita Patel, Sonal Rastogi, James Garvin |
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| Rok vydání: | 2018 |
| Předmět: |
BONE MARROW HARVEST
Adolescent Cd34 cells CD34 Priming (immunology) Antigens CD34 Granulocyte 03 medical and health sciences 0302 clinical medicine Granulocyte Colony-Stimulating Factor Humans Medicine Sibling Child Bone Marrow Transplantation Transplantation business.industry Siblings Hematology Tissue Donors Granulocyte colony-stimulating factor medicine.anatomical_structure Child Preschool 030220 oncology & carcinogenesis Practice Guidelines as Topic Immunology Bone marrow business 030215 immunology |
| Zdroj: | Biology of Blood and Marrow Transplantation. 24:324-329 |
| ISSN: | 1083-8791 |
| Popis: | To ensure optimal clinical outcomes for patients while retaining adequate protection for donors, the National Marrow Donor Program developed guidelines specifying that up to 20 mL/kg of bone marrow can be harvested from donors. These guidelines, originally developed for unrelated adult donors, are followed in children as well. We studied the impact of granulocyte colony-stimulating factor (G-CSF) priming on the cellular composition of harvested bone marrow, sought to develop an algorithm to optimize bone marrow harvest volume from pediatric matched sibling donors, and studied the impact of CD34+ cell dose on clinical outcomes. We analyzed data from 92 bone marrow harvests and clinical outcomes for 69 sibling recipient-donor duos, The mean age of recipients was 9.85 ± 5.90 years, and that of donors was 11.85 ± 6.36 years. G-CSF priming was not associated with higher yield of CD34+ cells/µL. The median CD34+ cell count obtained from donors was 700 cells/µL (range, 400-1700 cells/µL) in donors age 12 years (P |
| Databáze: | OpenAIRE |
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