Increased Intracranial Hemorrhage Amid Elevated Inflammatory Markers in those with COVID-19 Supported with Extracorporeal Membrane Oxygenation
| Autor: | Christian A. Bermudez, Federico Sertic, Jonah Rubin, Masaki Funamoto, Thomas Richards, Jerome C. Crowley, Molly Wolf, Salim E. Olia, Yuval Raz, Rene S Bermea, Kenneth Shelton |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male ARDS medicine.medical_treatment 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Procalcitonin Mitochondrial Proteins 03 medical and health sciences Extracorporeal Membrane Oxygenation 0302 clinical medicine Coagulopathy Extracorporeal membrane oxygenation Humans Medicine Respiratory system Pandemics Retrospective Studies SARS-CoV-2 business.industry Incidence COVID-19 030208 emergency & critical care medicine Retrospective cohort study Middle Aged medicine.disease United States surgical procedures operative Anesthesia Etiology Emergency Medicine Female Apoptosis Regulatory Proteins business Complication Intracranial Hemorrhages Biomarkers Follow-Up Studies |
| Zdroj: | Shock |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/shk.0000000000001730 |
| Popis: | COVID-19-related coagulopathy is a known complication of SARS-CoV-2 infection and can lead to intracranial hemorrhage (ICH), one of the most feared complications of extracorporeal membrane oxygenation (ECMO). We sought to evaluate the incidence and etiology of ICH in patients with COVID-19 requiring ECMO. Patients at two academic medical centers with COVID-19 who required venovenous-ECMO support for acute respiratory distress syndrome (ARDS) were evaluated retrospectively. During the study period, 33 patients required ECMO support; 16 (48.5%) were discharged alive, 13 died (39.4%), and 4 (12.1%) had ongoing care. Eleven patients had ICH (33.3%). All ICH events occurred in patients who received intravenous anticoagulation. The ICH group had higher C-reactive protein (pâ=â0.04), and procalcitonin levels (pâ=â0.02), and IL-6 levels (pâ=â0.05), lower blood pH before and after ECMO (pâ |
| Databáze: | OpenAIRE |
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