Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism

Autor: Olga Castañer Nino, Rafael de la Torre, Ester Civit, Jose Rodríguez-Morató, Albert Goday Arno, José M. Ramón, Luis Grande, David Benaiges Boix, Manuel Pera, Marcel·li Carbó, Esther Papaseit, Klaus Langohr, Magí Farré, Clara Pérez-Mañá, Juana A. Flores-Le Roux
Přispěvatelé: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Sleeve gastrectomy
Combinatorial analysis
Biomatemàtica
Gastric bypass
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
05 Combinatorics::05B Designs and configurations [Classificació AMS]
Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC]
030209 endocrinology & metabolism
Combinatòria
030226 pharmacology & pharmacy
Morbid obesity
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
60 Probability theory and stochastic processes::60C05 Combinatorial probability [Classificació AMS]
Pharmacokinetics
Obesitat mòrbida -- Cirurgia
Caffeine
medicine
Matemàtiques i estadística::Probabilitat [Àrees temàtiques de la UPC]
Paraxanthine
Biomathematics
Nutrition and Dietetics
Gastric emptying
business.industry
CYP1A2
92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS]
Surgery
Bioavailability
Clinical trial
Metabolism
Paracetamol
chemistry
Cafeïna
Combinatorial probabilities
Probabilitats
Metabolism paracetamol
Liver function
business
Zdroj: Obesity Surgery
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Recercat. Dipósit de la Recerca de Catalunya
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
ISSN: 0960-8923
Popis: PURPOSE: The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). MATERIALS AND METHODS: In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study. RESULTS: Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery. CONCLUSIONS: Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).
Databáze: OpenAIRE
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