LncRNA co-expression network analysis reveals novel biomarkers for pancreatic cancer
| Autor: | Francesco Piva, Matteo Giulietti, Alessandra Righetti, Giovanni Principato |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research endocrine system diseases Systems biology Gene regulatory network Datasets as Topic Biology 03 medical and health sciences 0302 clinical medicine Pancreatic cancer Biomarkers Tumor medicine Humans Gene Regulatory Networks Pancreas Survival rate Survival analysis Regulation of gene expression Gene Expression Profiling Systems Biology Cancer General Medicine Prognosis medicine.disease Survival Analysis digestive system diseases Gene Expression Regulation Neoplastic Pancreatic Neoplasms Survival Rate Gene expression profiling 030104 developmental biology 030220 oncology & carcinogenesis Cancer research RNA Long Noncoding Carcinoma Pancreatic Ductal |
| Zdroj: | Carcinogenesis. 39:1016-1025 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/bgy069 |
| Popis: | High mortality and low survival rates for pancreatic ductal adenocarcinoma (PDAC) mainly result from the delay in diagnosis and treatment. Therefore, there is an urgent need to identify early PDAC biomarkers and new therapeutic targets. In this study, we applied a commonly used systems biology approach, the weighted gene co-expression network analysis (WGCNA), on lncRNA expression data. Eleven lncRNAs, namely A2M-AS1, DLEU2, LINC01133, LINC00675, MIR155HG, SLC25A25-AS1, LINC01857, LOC642852 (LINC00205), ITGB2-AS1, TSPOAP1-AS1 and PSMB8-AS1 have been identified and validated on an independent PDAC expression dataset. Furthermore, we characterized them by functional and pathway enrichment analysis and identified which lncRNAs showed differential expression, differential promoter methylation levels and copy number alterations between normal and PDAC samples. Finally, we also performed a survival analysis and identified A2M-AS1, LINC01133, LINC00205 and TSPOAP1-AS1 as prognostic biomarkers for PDAC. Interestingly, although only a few cancer-associated lncRNAs have been functionally characterized, LINC00675 and LINC01133 lncRNAs have already been demonstrated to be involved in PDAC development and progression. Therefore, our results provide new potential diagnostic/prognostic biomarkers and therapeutic targets for PDAC that deserve to be further investigated. Moreover, these lncRNAs may improve the understanding about molecular pathogenesis of PDAC. |
| Databáze: | OpenAIRE |
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