Opioid-dopaminergic mechanisms in the potentiation of d-amphetamine discrimination by interferon-α
| Autor: | Victor A. Levin, Jian-Guo Lu, Beng T. Ho, Yuang-Yi Huo, L.Wayne Tansey |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Dextroamphetamine medicine.drug_class Dopamine Clinical Biochemistry Alpha interferon (+)-Naloxone Pharmacology Toxicology Biochemistry Extinction Psychological Behavioral Neuroscience Discrimination Psychological Opioid receptor Internal medicine medicine Animals Amphetamine Opioid peptide Biological Psychiatry Interferon alfa Chemistry Antagonist Interferon-alpha Rats Inbred Strains Rats Endocrinology Opioid Endorphins medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 42:57-60 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(92)90446-m |
| Popis: | In rats trained to discriminate 0.8 mg/kg IP d-amphetamine from 1 ml/kg saline, 4 x 10(6) U/kg of recombinant human interferon-alpha (rIFN-alpha) given intramuscularly 1 h prior to tests potentiated responses elicited by 0.4 mg/kg d-amphetamine. Coadministration of the opioid receptor antagonist naloxone (1 mg/kg IP) with rIFN-alpha suppressed the potentiation of d-amphetamine by the cytokine. Opioid-dopaminergic mechanisms are proposed to explain the action of rIFN-alpha. |
| Databáze: | OpenAIRE |
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