Optical Coherence Tomography for Noninvasive Diagnosis and Subtyping of Basal Cell Carcinoma
| Autor: | Eva van Loo, Klara Mosterd, Patty J. Nelemans, Véronique Winnepenninckx, Nicole W.J. Kelleners-Smeets, Erwin H.J. Tonk, Kelly A.E. Sinx |
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| Přispěvatelé: | MUMC+: MA AIOS Dermatologie (9), Dermatologie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Dermatologie (9), Pathologie, MUMC+: DA Pat Pathologie (9), RS: GROW - R2 - Basic and Translational Cancer Biology, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Skin Neoplasms Physical examination Dermatology Biochemistry Sensitivity and Specificity Lesion 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Biopsy OPERATING CHARACTERISTIC CURVES medicine Humans Basal cell carcinoma Prospective Studies Prospective cohort study Molecular Biology Aged Aged 80 and over integumentary system medicine.diagnostic_test Receiver operating characteristic business.industry Cell Biology Gold standard (test) Middle Aged medicine.disease 030104 developmental biology Carcinoma Basal Cell 030220 oncology & carcinogenesis Female Radiology medicine.symptom business Tomography Optical Coherence |
| Zdroj: | Journal of Investigative Dermatology, 140(10), 1962-1967. Elsevier Science |
| ISSN: | 0022-202X |
| Popis: | Noninvasive diagnostic strategies such as optical coherence tomography (OCT) enable detailed examination of skin tissue architecture and have potential for identification and subtyping of basal cell carcinoma (BCC). To evaluate the additional diagnostic value of OCT, a prospective cohort study was performed in 182 patients with 250 lesions suspected for non-melanoma skin premalignancies requiring a biopsy. Accuracy of BCC diagnosis and subtype on the basis of clinical examination (CE) of patients was compared with that on the basis of OCT scans in conjunction with clinical images of lesions (cOCT). Confidence levels were recorded on a 5-point scale, where score 0 indicated absence of BCC and scores 1-4 indicated increasing suspicion of BCC. Diagnostic performance parameters were compared using histopathologic diagnosis as gold standard. The patient-based area under the receiver operating characteristic curve (AUC) increased from 85.6% for CE to 91.2% for cOCT (P = 0.061) and the lesion-based AUC from 82.7% to 91.3% (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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