Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis
| Autor: | Karen K. Miller, Jan Frystyk, Mikkel Andreassen, Lars Østergaard Kristensen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Thyroid Hormones medicine.medical_specialty Multiple Sclerosis Hydrocortisone medicine.medical_treatment Clinical Biochemistry Administration Oral Growth hormone Article Central nervous system disease Internal medicine Acromegaly medicine Humans Glucose tolerance test Estradiol medicine.diagnostic_test business.industry Multiple sclerosis Growth factor Interferon-beta General Medicine Glucose Tolerance Test medicine.disease Pituitary Hormones Glucose Cytokine Endocrinology Growth Hormone Female business medicine.drug |
| Zdroj: | Andreassen, M, Frystyk, J, Miller, K K & Kristensen, L 2010, ' Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 70, no. 7, pp. 519-22 . https://doi.org/10.3109/00365513.2010.521256 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365513.2010.521256 |
| Popis: | We describe a 34-year-old female treated with IFN-β for 8 years with a biochemical profile suggestive of acromegaly. The patient presented with elevated serum insulin-like growth factor-I (IGF-I) and insufficient suppression of growth hormone (GH) during oral glucose tolerance test (OGTT). There were no clinical features of acromegaly. A 5-day profile showed higher GH levels on the 3 days following IFN-β injections. Total and bioactive IGF-I were also elevated but did not fluctuate. Four weeks off IFN-β normalized suppression of GH during OGTT but did not reduce serum IGF-I or bioactive IGF-I. In conclusion, IFN-β treatment mimicked acromegaly biochemically. The changes were partially reversible. |
| Databáze: | OpenAIRE |
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