Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa
| Autor: | Bing Nan Han, Mark T. Hamann, Shao Jiang Song, Fan Yang, Hong Jun Zhang, Hou-Wen Lin, Wei-Hua Jiao, Yike Zou, Ru Ping Wang |
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| Rok vydání: | 2014 |
| Předmět: |
China
South china Stereochemistry Oceans and Seas Diacarnus megaspinorhabdosa Plasmodium falciparum Diol Pharmaceutical Science Stereoisomerism Article Antimalarials chemistry.chemical_compound Cell Line Tumor Drug Discovery Animals Humans antimalarial marine sponge endoperoxide 14. Life underwater lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Molecular Structure biology biology.organism_classification Peroxides Porifera Sponge lcsh:Biology (General) chemistry Diterpenes Drug Screening Assays Antitumor |
| Zdroj: | Marine Drugs, Vol 12, Iss 8, Pp 4399-4416 (2014) Marine Drugs Marine Drugs; Volume 12; Issue 8; Pages: 4399-4416 |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md12084399 |
| Popis: | Five new norditerpene endoperoxides, named diacarperoxides H–L (1–5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H–J (1–3) showed some interesting stereochemical issues, as well as antimalarial activity. |
| Databáze: | OpenAIRE |
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