A risk prediction model for fetal hypospadias by testing maternal serum AFP and free beta-HCG
| Autor: | Jin Mei, Yiming Chen, Jianxia Huang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Clinical Biochemistry Prenatal diagnosis 030204 cardiovascular system & hematology Free human chorionic gonadotropin beta subunit 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Prenatal Diagnosis medicine Humans Chorionic Gonadotropin beta Subunit Human Hypospadias Fetus Receiver operating characteristic Obstetrics business.industry General Medicine medicine.disease Confidence interval ROC Curve Area Under Curve Case-Control Studies embryonic structures Free beta hcg Female alpha-Fetoproteins Alpha-fetoprotein business |
| Zdroj: | Clinical Biochemistry. 69:21-25 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2019.05.015 |
| Popis: | Objective We aimed to determine the correlation between serum alpha-fetoprotein (AFP), the free human chorionic gonadotropin beta subunit (free beta-HCG) in pregnant women during the mid-trimester, and fetal hypospadias, and tried to establish a risk prediction model. Methods A multi-center case-control study was conducted. We divided the fetuses into two groups (69 with fetal hypospadias and 62 without fetal hypospadias). Time-resolved immunofluorescence was used to determine the serum levels of AFP and free beta-HCG. The best cut -value and area under curve (AUC) were determined based on the Receiver operating characteristics (ROC) curve, and the diagnostic value of AFP and free beta-HCG was evaluated. Results The level of AFP in the study group was 1.14 multiple of Median(MOM), which was higher than in the control group (0.96 MOM); the difference was significant (Z = 2.831, P = .005). Similarly, the free beta-HCG level was 1.30 MOM in the study group, and was also significantly higher than in the control group (0.84 MOM; Z = 3.131, P = .004). We used the AFP and free beta-HCG levels separately to predict fetuses with hypospadias, and the AUCs were 0.644 (95% Confidence interval (CI): 0.5500.737, P = .005) and 0.659 (95% CI: 0.5650.752, P = .002), respectively. According to the ROC curve, the best cut-off values for AFP and free beta-HCG were 0.945 MOM and 1.275 MOM, respectively. When we combined the AFP level with the free beta-HCG level, the AUC was 0.700 (95% CI: 0.610–0.789, P Conclusion Combined screening for fetal hypospadias with maternal serum AFP and free beta-HCG levels during the early second trimester has high sensitivity and specificity, which can be used as a new marker. |
| Databáze: | OpenAIRE |
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