Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice
| Autor: | Andrew J. Grant, Rob Deardon, Gemma L. Foster, Duncan J. Maskell, Clare E. Bryant, Pietro Mastroeni, Mark Sheppard, Sam P. Brown |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Salmonella typhimurium
Programmed cell death Necrosis Phagocyte caspase Immunology Apoptosis Caspase 3 DNA Fragmentation Microbiology necrosis Mice systemic infection In Situ Nick-End Labeling medicine Animals Immunology and Allergy Caspase Mice Inbred BALB C Phagocytes Salmonella Infections Animal biology apoptosis Original Articles biology.organism_classification Virology Mice Inbred C57BL Toll-Like Receptor 4 medicine.anatomical_structure Liver Microscopy Fluorescence Salmonella enterica biology.protein Female medicine.symptom Intracellular |
| Zdroj: | Grant, A J, Sheppard, M, Deardon, R, Brown, S P, Foster, G, Bryant, C E, Maskell, D J & Mastroeni, P 2008, ' Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice ', Immunology, vol. 125, no. 1, pp. 28-37 . https://doi.org/10.1111/j.1365-2567.2008.02814.x |
| DOI: | 10.1111/j.1365-2567.2008.02814.x |
| Popis: | Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can undergo apoptotic caspase-3-mediated cell death in vivo, with apoptosis being a rare event, more prevalent in heavily infected cells. The density-dependent apoptotic cell death is likely to constitute an alternative mechanism of bacterial spread as part of a bet-hedging strategy, ensuring an ongoing protective intracellular environment in which some bacteria can grow and persist. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|