A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis
| Autor: | Stephen J. Walker, John E. Fortunato, Daniel P. Beavers, Arthur Krigsman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Autism Spectrum Disorder Colon Inflammation Disease Biology Inflammatory bowel disease Gastroenterology Article Young Adult 03 medical and health sciences 0302 clinical medicine Ileum Internal medicine Biopsy medicine Humans Intestinal Mucosa Child Oligonucleotide Array Sequence Analysis Principal Component Analysis Multidisciplinary medicine.diagnostic_test Inflammatory Bowel Diseases medicine.disease Ulcerative colitis 030104 developmental biology ROC Curve Autism spectrum disorder Area Under Curve Case-Control Studies Child Preschool Immunology Cohort RNA Biomarker (medicine) Colitis Ulcerative Female medicine.symptom Transcriptome Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep35820 |
| Popis: | Gastrointestinal symptoms are common in children with autism spectrum disorder (ASD). A significant proportion of children with ASD and gastrointestinal symptoms have histologic evidence of ileocolitis (inflammation of the terminal ileum and/or colon). We previously reported the molecular characterization of gastrointestinal biopsy tissue from ASD children with ileocolitis (ASDIC+) compared to anatomically similar inflamed tissue from typically developing children with inflammatory bowel disease (IBD; i.e. Crohn’s disease or ulcerative colitis) and typically developing children with gastrointestinal symptoms but no evidence of gastrointestinal mucosal inflammation (TDIC−). ASDIC+ children had a gene expression profile that, while primarily overlapping with known IBD, had distinctive differences. The present study confirms these findings and replicates this molecular characterization in a second cohort of cases (ASDIC+) and controls (TDIC−). In these two separate case/control mucosal-based cohorts, we have demonstrated overlap of 59 differentially expressed transcripts (DETs) unique to inflamed ileocolonic tissue from symptomatic ASDIC+ children. We now report that 9 of these 59 transcripts are also differentially expressed in the peripheral blood of the second cohort of ASDIC+ children. This set of transcripts represents a putative blood-based biomarker for ASD-associated ileocolonic inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|