Anti-ulcer role of herbomineral siddha drug — Thamira parpam on experimentally induced gastric mucosal damage in rats
| Autor: | H. Balaji Raghavendran, V. Vijaya Kumar, M. Vasanthkumar, D. Chamundeeswari, Hannah R. Vasanthi, M.K. Sangeetha, R. P. Parameswari, V. Gayathri |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Antioxidant Thiobarbituric acid Health Toxicology and Mutagenesis medicine.medical_treatment Pharmacology Toxicology medicine.disease_cause Severity of Illness Index Thiobarbituric Acid Reactive Substances Antioxidants Superoxide dismutase chemistry.chemical_compound medicine TBARS Animals Stomach Ulcer Antipyretic Rats Wistar Nitrites chemistry.chemical_classification Glutathione Peroxidase Aspirin Ethanol biology Plant Extracts Superoxide Dismutase Chemistry Glutathione peroxidase Body Weight Gastric Acidity Determination General Medicine Glutathione Anti-Ulcer Agents Medicine Ayurvedic Rats Disease Models Animal Oxidative Stress Biochemistry Cytoprotection Gastric Mucosa biology.protein Hydrochloric Acid Lipid Peroxidation Plant Preparations Oxidative stress medicine.drug |
| Zdroj: | Human & Experimental Toxicology. 29:161-173 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327109357217 |
| Popis: | Anti-ulcerogenic activity of Thamira parpam (TP) was investigated in two ulcer models (aspirin + pylorus ligation and HCl-ethanol). Aspirin—pylorus ligation (Asp 200 mg/kg-7 days + PL-4 hours) and HCl-ethanol (150 mM HCl in 70% ethanol) induction in rat resulted in elevation of thiobarbituric acid reactive substances (TBARS) and depletion of antioxidants (superoxide dismutase [SOD], glutathione [GSH], glutathione peroxidase [GPx]) with high ulcer scores (p < .01). In Asp + PL model, TP treatment showed mild inhibition on ulcer scores, changes in pH, gastric volume, total and free acidity, and elevation of TBARS and depletion of antioxidants. Compared to the ulcer-untreated rats (HCl-ethanol), the herbomineral drug TP treatment (0.5, 1, 2 mg/kg, per oral [p.o.]) attenuated the elevation of TBARS, decrease of antioxidants and nitrite (p < .05). Histopathological examinations were correlated with the antioxidant profile. In conclusion, the prophylactic cytoprotective nature of the herbomineral drug in experimentally induced ulcers could be mediated by its free radical quenching property. |
| Databáze: | OpenAIRE |
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