Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia
| Autor: | Abel Wade, Philippe Totté, Amadou Sery, Aboubakar YaYa, Jan Naessens, Hezron Wesonga, François Thiaucourt, Mamadou Niang |
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| Přispěvatelé: | Contrôle des maladies animales exotiques et émergentes (UMR CMAEE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Natl Vet Lab, Partenaires INRAE, Laboratoire Central Vétérinaire [Bamako, Mali], Kenya Agricultural Research Institute, International Livestock Research Institute [CGIAR, Nairobi] (ILRI), International Livestock Research Institute [CGIAR, Ethiopie] (ILRI), Consultative Group on International Agricultural Research [CGIAR] (CGIAR)-Consultative Group on International Agricultural Research [CGIAR] (CGIAR), European Union, under the supervision of OAU/IBAR (Kenya), Australian aid program, CSIRO-AUSaid grant |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
CD4-Positive T-Lymphocytes
[SDV]Life Sciences [q-bio] Lymphocyte Veterinary Microbiology lcsh:Medicine L73 - Maladies des animaux 0403 veterinary science Péripneumonie contagieuse bovine Contagious bovine pleuropneumonia Immunologie Medicine lcsh:Science Immune Response 0303 health sciences Multidisciplinary biology T Cells Vaccination Mycoplasma mycoides 04 agricultural and veterinary sciences Veterinary Bacteriology Flow Cytometry 3. Good health Bacterial vaccine Infectious Diseases medicine.anatomical_structure Veterinary Diseases Bacterial Vaccines Research Article Neglected Tropical Diseases Veterinary Medicine 040301 veterinary sciences Vaccin Immune Cells T cell Immunology Cattle Diseases Enzyme-Linked Immunosorbent Assay Veterinary Immunology 03 medical and health sciences Immune system Immunity Animals L50 - Physiologie et biochimie animales Pleuropneumonia Contagious Biology 030304 developmental biology Bovin business.industry lcsh:R Réponse immunitaire biology.organism_classification medicine.disease Clinical Immunology Veterinary Science Cattle lcsh:Q business Immunologic Memory |
| Zdroj: | PloS One PLoS ONE, Vol 8, Iss 2, p e57509 (2013) Plos One 2 (8), . (2013) PLoS ONE PLoS ONE, Public Library of Science, 2013, 8 (2), ⟨10.1371/journal.pone.0057509⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0057509⟩ |
| Popis: | International audience; A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-gamma responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4(+) T lymphocytes. Moreover, CD62L expression indicated that both CD4(+) effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines. |
| Databáze: | OpenAIRE |
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