Loss of Breathing Modulation of Heart Rate Variability in Patients with Recent and Long Standing Diabetes Mellitus Type II

Autor: J. C. Toledo-Roy, Ruben Fossion, José A. Callejas-Rojas, Bruno Estañol, Ana Leonor Rivera, José Antonio Gien-López, Guillermo Delgado-García, Alejandro Frank
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Supine position
Physiology
Hemodynamics
lcsh:Medicine
Blood Pressure
030204 cardiovascular system & hematology
Vascular Medicine
Electrocardiography
Endocrinology
Mathematical and Statistical Techniques
0302 clinical medicine
Heart Rate
Medicine and Health Sciences
Heart rate variability
Medicine
lcsh:Science
Multidisciplinary
Fourier Analysis
Respiration
Hematology
Middle Aged
Breathing
Anesthesia
Female
Research Article
Interbeat interval
Adult
Endocrine Disorders
Cardiology
030209 endocrinology & metabolism
Research and Analysis Methods
Young Adult
03 medical and health sciences
Reflex
Heart rate
Diabetes Mellitus
Humans
Balance and Falls
business.industry
lcsh:R
Biology and Life Sciences
Autonomic nervous system
Blood pressure
Diabetes Mellitus
Type 2
Geriatrics
Metabolic Disorders
lcsh:Q
Physiological Processes
business
Zdroj: PLoS ONE, Vol 11, Iss 11, p e0165904 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Healthy subjects under rhythmic breathing have heart interbeat intervals with a respiratory band in the frequency domain that can be an index of vagal activity. Diabetes Mellitus Type II (DM) affects the autonomic nervous system of patients, thus it can be expected changes on the vagal activity. Here, the influence of DM on the breathing modulation of the heart rate is evaluated by analyzing in the frequency domain heart interbeat interval (IBI) records obtained from 30 recently diagnosed, 15 long standing DM patients, and 30 control subjects during standardized clinical tests of controlled breathing at 0.1 Hz, supine rest and standing upright. Fourier spectral analysis of IBI records quantifies heart rate variability in different regions: low-frequencies (LF, 0.04–0.15 Hz), high-frequencies (HF, 0.15–0.4 Hz), and a controlled breathing peak (RP, centered around 0.1 Hz). Two new parameters are introduced: the frequency radius rf (square root of the sum of LF and HF squared) and β (power of RP divided by the sum of LF and HF). As diabetes evolves, the controlled breathing peak loses power and shifts to smaller frequencies, indicating that heart rate modulation is slower in diabetic patients than in controls. In contrast to the traditional parameters LF, HF and LF/HF, which do not show significant differences between the three populations in neither of the clinical tests, the new parameters rf and β, distinguish between control and diabetic subjects in the case of controlled breathing. Sympathetic activity that is driven by the baroreceptor reflex associated with the 0.1 Hz breathing modulations is affected in DM patients. Diabetes produces not only a rigid heartbeat with less autonomic induced variability (rf diminishes), but also alters the coupling between breathing and heart rate (reduced β), due to a progressive decline of vagal and sympathetic activity.
Databáze: OpenAIRE
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