Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review

Autor: Wenjie Zhang, Reza Taheri-Ledari, Fatemeh Ganjali, Seyedeh Shadi Mirmohammadi, Fateme Sadat Qazi, Mahdi Saeidirad, Amir KashtiAray, Simindokht Zarei-Shokat, Ye Tian, Ali Maleki
Rok vydání: 2023
Předmět:
Zdroj: RSC Advances. 13:80-114
ISSN: 2046-2069
DOI: 10.1039/d2ra06888e
Popis: In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the penetration of a cell membrane. In this regard, several studies have focused on methods to produce nanorods and nanotubes with controlled optimized size and aspect ratio (AR). Additionally, a non-spherical orientation could affect the cellular uptake process while a tangent angle of less than 45° is better at penetrating the membrane, and
Databáze: OpenAIRE