Transient RNA structure features are evolutionarily conserved and can be computationally predicted
| Autor: | Jeff R. Proctor, Jing Yun A. Zhu, Irmtraud M. Meyer, Adi Steif |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Genetics
Riboswitch 0303 health sciences RNA Folding Base pair 030302 biochemistry & molecular biology RNA Computational Biology Computational biology Biology Non-coding RNA Evolution Molecular 03 medical and health sciences Regulatory sequence Sequence Homology Nucleic Acid Nucleic acid Nucleic Acid Conformation Nucleic acid structure Gene Software 030304 developmental biology |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 |
| Popis: | Functional RNA structures tend to be conserved during evolution. This finding is, for example, exploited by comparative methods for RNA secondary structure prediction that currently provide the state-of-art in terms of prediction accuracy. We here provide strong evidence that homologous RNA genes not only fold into similar final RNA structures, but that their folding pathways also share common transient structural features that have been evolutionarily conserved. For this, we compile and investigate a non-redundant data set of 32 sequences with known transient and final RNA secondary structures and devise a dedicated computational analysis pipeline. |
| Databáze: | OpenAIRE |
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