Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla

Autor: Attilio Di Pietro, Marie-Geneviève Dijoux-Franca, Binh Hoa Phung, Charles Dumontet, Agnès Doreau, Van Thi Bao Nguyen, Nicole Darbour, Imad Raad, David Guilet, Christine Bayet
Přispěvatelé: Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL)
Rok vydání: 2008
Předmět:
Angiosperms
[SDV]Life Sciences [q-bio]
Saponin
Drug Resistance
Pharmacognosy
0302 clinical medicine
Drug Discovery
ATP Binding Cassette Transporter
Subfamily G
Member 2
P-glycoprotein
chemistry.chemical_classification
0303 health sciences
Leukemia
biology
Paris polyphylla
General Medicine
Drug Resistance
Multiple
3. Good health
Neoplasm Proteins
Ecdysterone
030220 oncology & carcinogenesis
Cyclosporine
Steroids
Efflux
Multidrug Resistance-Associated Proteins
Multiple
Immunosuppressive Agents
medicine.drug
medicine.medical_specialty
Daunorubicin
Diosgenin
03 medical and health sciences
Magnoliopsida
Internal medicine
Membrane Transport Modulators
medicine
Spirostans
Humans
ATP Binding Cassette Transporter
Subfamily B
Member 1
030304 developmental biology
Pharmacology
Plant Extracts
P-Glycoprotein
Ecdysteroids
Saponins
biology.organism_classification
Molecular biology
Multiple drug resistance
carbohydrates (lipids)
Endocrinology
chemistry
Drug Resistance
Neoplasm
Trilliaceae
biology.protein
Neoplasm
ATP-Binding Cassette Transporters
K562 Cells
Rhizome
Zdroj: Fitoterapia
Fitoterapia, Elsevier, 2009, 80 (1), pp.39-42. ⟨10.1016/j.fitote.2008.09.010⟩
ISSN: 1873-6971
0367-326X
DOI: 10.1016/j.fitote.2008.09.010⟩
Popis: International audience; Bio-guided fractionation of the roots of Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-O-Rha(12)[Ara(14)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux.
Databáze: OpenAIRE
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