Associating high intensity and modulated frequency of TENS delays analgesic tolerance in rats
| Autor: | L.V. Lima, T.S.S. Abner, Clarissa M.D. Mota, Valter J. Santana-Filho, Josimari Melo DeSantana, Kamilla M.L. Cruz, M.E.J. Agripino |
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| Rok vydání: | 2014 |
| Předmět: |
Analgesic effect
Male Pain Threshold medicine.medical_specialty Analgesic Stimulation Sensory system Transcutaneous electrical nerve stimulation law.invention Mechanical Hyperalgesia law medicine Animals Rats Wistar business.industry High intensity Arthralgia Arthritis Experimental Surgery Intensity (physics) Rats Disease Models Animal Anesthesiology and Pain Medicine Hyperalgesia Anesthesia Transcutaneous Electric Nerve Stimulation business |
| Zdroj: | European journal of pain (London, England). 19(3) |
| ISSN: | 1532-2149 |
| Popis: | Background Transcutaneous electrical nerve stimulation (TENS) is a non-invasive analgesic resource extensively used in painful conditions. However, preclinical studies suggest that the prolonged use of TENS results in the development of tolerance to its analgesic effect. The present study investigated the analgesic effect and development of tolerance to TENS with four different stimulation protocols. Methods Male Wistar rats induced with joint inflammation were divided into four groups: sensory intensity, low motor intensity, high motor intensity and sham groups. TENS was applied daily for 20 min with alternating frequency between 4 and 100 Hz until tolerance development was evidenced. Mechanical hyperalgesia was measured before and after each TENS daily application. Results After TENS, tolerance was evidenced There was a significant reduction in the mechanical withdrawal threshold in all groups 24 h after induction of inflammation (p |
| Databáze: | OpenAIRE |
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