Ischemia/reperfusion in rat: antioxidative effects of enoant on EEG, oxidative stress and inflammation
| Autor: | Sevilcan Tuna, Ilknur Özen, Makbule Aydin, Ihsan Kara, Asiye Nurten, Sacit Karamürsel, Bilge Özerman, Elif Ozkok |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Neurology Neuroscience (miscellaneous) Ischemia Inflammation Pharmacology medicine.disease_cause Antioxidants Brain Ischemia Beverages Basal (phylogenetics) chemistry.chemical_compound Random Allocation medicine.artery Developmental and Educational Psychology medicine TBARS Animals Vitis Common carotid artery Rats Wistar business.industry Electroencephalography Glutathione medicine.disease Rats Oxidative Stress chemistry Anesthesia Reperfusion Injury Reperfusion Neurology (clinical) medicine.symptom business Oxidative stress |
| Zdroj: | Brain injury. 25(1) |
| ISSN: | 1362-301X |
| Popis: | The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury.Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg⁻¹ per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-α, IL-1β and IL-6, TBARS and GSH were measured in the whole brain homogenate.There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-α, IL-6 and IL-1β levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group.The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia. |
| Databáze: | OpenAIRE |
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