Raman Spectroscopy of Blood and Blood Components
| Autor: | Chad G. Atkins, Robin F. B. Turner, Kevin Buckley, Michael W. Blades |
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| Rok vydání: | 2017 |
| Předmět: |
Male
chemistry.chemical_element 02 engineering and technology Electrolyte Spectrum Analysis Raman 01 natural sciences Oxygen Hemoglobins Mice symbols.namesake Animals Humans Platelet Instrumentation Spectroscopy Whole blood Hematologic Tests 010401 analytical chemistry Metabolism Surface-enhanced Raman spectroscopy 16. Peace & justice 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences chemistry symbols Biophysics Female Hemoglobin 0210 nano-technology Raman spectroscopy Biomarkers Blood Chemical Analysis |
| Zdroj: | Applied Spectroscopy. 71:767-793 |
| ISSN: | 1943-3530 0003-7028 |
| DOI: | 10.1177/0003702816686593 |
| Popis: | Blood is a bodily fluid that is vital for a number of life functions in animals. To a first approximation, blood is a mildly alkaline aqueous fluid (plasma) in which a large number of free-floating red cells (erythrocytes), white cells (leucocytes), and platelets are suspended. The primary function of blood is to transport oxygen from the lungs to all the cells of the body and move carbon dioxide in the return direction after it is produced by the cells’ metabolism. Blood also carries nutrients to the cells and brings waste products to the liver and kidneys. Measured levels of oxygen, nutrients, waste, and electrolytes in blood are often used for clinical assessment of human health. Raman spectroscopy is a non-destructive analytical technique that uses the inelastic scattering of light to provide information on chemical composition, and hence has a potential role in this clinical assessment process. Raman spectroscopic probing of blood components and of whole blood has been on-going for more than four decades and has proven useful in applications ranging from the understanding of hemoglobin oxygenation, to the discrimination of cancerous cells from healthy lymphocytes, and the forensic investigation of crime scenes. In this paper, we review the literature in the field, collate the published Raman spectroscopy studies of erythrocytes, leucocytes, platelets, plasma, and whole blood, and attempt to draw general conclusions on the state of the field. |
| Databáze: | OpenAIRE |
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