The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer
| Autor: | D. A. Morgacheva, Yu. V. Dinikina, Yu. K. Toshina, M. B. Belogurova |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment translocation chemotherapy 03 medical and health sciences 0302 clinical medicine medicine Mucositis Diseases of the blood and blood-forming organs Gastrointestinal tract Chemotherapy business.industry Cancer Hematology pediatric oncology medicine.disease Antimicrobial intestinal microbiome 030104 developmental biology Graft-versus-host disease mucositis febrile neutropenia Oncology 030220 oncology & carcinogenesis Immunology RC633-647.5 business Dysbiosis Febrile neutropenia |
| Zdroj: | Onkogematologiâ, Vol 16, Iss 2, Pp 86-93 (2021) |
| ISSN: | 1818-8346 |
| Popis: | Infectious complications remain one of the most significant problem associated with anticancer therapy in oncological patients. Cytotoxic, radiation and antibacterial therapy induce dysbiosis and gastrointestinal mucosal barrier injury. These changes lead to the mucositis, thereby increasing the risk of endogenous microflora translocation with following probable development of severe infectious and inflammatory diseases. In addition, current evidence suggests that there is a relationship between gut microbiome disturbances and post-transplant graft versus host disease development. The article presents the existing paradigms of determining the role of gastrointestinal tract functional condition in cancer patients in order to optimize prevention and antimicrobial treatment approaches. |
| Databáze: | OpenAIRE |
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