Comparison of patient reported quality of life and impact of treatment side effects experienced with a taxane-containing regimen and standard anthracycline based chemotherapy for early breast cancer: 6year results from the UK TACT trial (CRUK/01/001)
| Autor: | Emma Hall, Tact Trial Investigators, Penelope Hopwood, Judith M Bliss, Rachel Waters, Peter Barrett-Lee, S. Russell, David Cameron, Peter M. Ellis |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Bridged-Ring Compounds Quality of life medicine.medical_specialty Cancer Research Anthracycline medicine.medical_treatment Breast Neoplasms Therapeutics Article law.invention Randomized controlled trial law Surveys and Questionnaires Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Chemotherapy Anthracyclines Breast Cyclophosphamide Patient reported outcomes Epirubicin Randomised controlled trial Taxane business.industry Standard treatment Middle Aged United Kingdom Tamoxifen Regimen Methotrexate Early Oncology Chemotherapy Adjuvant Physical therapy Female Taxoids Fluorouracil business medicine.drug |
| Zdroj: | European Journal of Cancer |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2014.06.007 |
| Popis: | Background The TACT trial (CRUK/01/001) compared adjuvant sequential FEC-docetaxel (FEC-D) chemotherapy with standard anthracycline-based chemotherapy of similar duration in women with early breast cancer. Results at a median of 5years suggested no improvement in disease-free survival with FEC-D. Given differing toxicity profiles of the regimens, the impact on quality of life (QL) was explored. Methods Patients from 44 centres completed standardised QL questionnaires before chemotherapy, after cycles 4 and 8, at 9, 12, 18 and 24months and at 6years follow-up. Patient diaries assessed frequency, associated distress and impact on daily activity of 15 treatment related side effects. Findings 830 patients (415 FEC-D; 415 controls) contributed assessments during 0–24months; 362 of whom participated again at 6years. During chemotherapy, FEC-D impaired global health/QL and depression rates and significantly more QL domains than standard regimens. Novel diary card ratings highlighted significantly more distress and interference with daily activities due to FEC-D side effects compared with standard treatment. In both groups, most QL parameters returned to baseline levels by 2years and were unchanged at 6years. Interpretation Within expected negative effects of chemotherapy on wide ranging QL domains FEC-D patients reported greater toxicity, disruption and distress during treatment with no improvement in disease outcome at 5years than patients receiving standard anthracycline-based chemotherapy. Findings should inform future patients of relative costs and benefits of adjuvant chemotherapy. |
| Databáze: | OpenAIRE |
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