Renal effects of amino acid infusion in cardiac surgery
| Autor: | Klaus Kirnö, Peter Friberg, Anders Jeppsson, I. Milocco, Sveneric Svensson, Rolf Ekroth, Folke Nilsson |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Increased glomerular filtration rate Thermodilution Urology Renal function Kidney Renal Circulation Coronary artery bypass surgery Oxygen Consumption medicine Humans Prospective Studies Amino Acids Coronary Artery Bypass Infusions Intravenous Aged chemistry.chemical_classification Aged 80 and over urogenital system business.industry Hemodynamics Middle Aged medicine.disease Surgery Amino acid Anesthesiology and Pain Medicine chemistry Renal blood flow Creatinine Renal vein Cardiology and Cardiovascular Medicine business Kidney disease Blood sampling Glomerular Filtration Rate |
| Zdroj: | Journal of cardiothoracic and vascular anesthesia. 14(1) |
| ISSN: | 1053-0770 |
| Popis: | To evaluate effects of amino acids on renal function and oxygen consumption and the role of individual amino acids on renal blood flow (RBF) changes.Prospective, randomized, controlled study.Operating room in cardiothoracic surgery department, university hospital.Twenty-two male patients submitted to elective first-time coronary artery bypass surgery.A catheter was placed in the left renal vein for thermodilution RBF measurements and blood sampling. In 11 patients, a balanced mixed amino acid infusion was infused (200 mL/hr) for 30 minutes immediately after the operation.RBF and glomerular filtration rate increased during amino acid infusion compared with the control group. Renal oxygen consumption increased in the amino acid group and correlated with the increase in RBF (r = 0.70, p0.001). Amino acid infusion induced two- to fourfold increases in plasma concentrations of individual amino acid concentrations and promoted renal extraction of aspartate, glutamate, glycine, and histidine. No correlation was observed between arterial concentration or uptake of individual amino acids and RBF.The increase in RBF from a mixed amino acid infusion was associated with increased glomerular filtration rate and renal consumption of oxygen. Changes in RBF of a mixed amino acid infusion could not be linked to plasma level or renal uptake of any individual amino acids. |
| Databáze: | OpenAIRE |
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