Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
| Autor: | Sanghyo Kim, Buddolla Viswanath, Prakash Thangavel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
High selectivity Biophysics Pharmaceutical Science chemistry.chemical_element Bioengineering Nanotechnology Antineoplastic Agents Review 010402 general chemistry Ligands 01 natural sciences cancer treatment Ruthenium Biomaterials Drug Delivery Systems Neoplasms Drug Discovery Humans chemistry.chemical_classification Low toxicity nanotechnology cell apoptosis 010405 organic chemistry Ligand Biomolecule Nanostructured materials Organic Chemistry toxicity General Medicine 0104 chemical sciences Cancer treatment Nanostructures chemistry Targeted drug delivery Photochemotherapy metallodrugs DNA damage Ruthenium Compounds |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 1176-9114 |
| Popis: | In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on "traditional" (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner. |
| Databáze: | OpenAIRE |
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