Redefining micrometastasis in prostate cancer - a comparison of circulating prostate cells, bone marrow disseminated tumor cells and micrometastasis: Implications in determining local or systemic treatment for biochemical failure after radical prostatectomy
| Autor: | R. Olivares, E. Reyes, N. Orellana, Nigel P Murray, J. Porcell, C Fuentealba, R. Dueñas, P. Tapia, L. Badinez |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Male medicine.medical_specialty Pathology Concordance medicine.medical_treatment Prostate cancer Antigen Bone Marrow Internal medicine Biopsy Genetics medicine Humans Prospective Studies Prospective cohort study Aged Aged 80 and over Prostatectomy medicine.diagnostic_test business.industry Micrometastasis Prostate Prostatic Neoplasms General Medicine Middle Aged Prostate-Specific Antigen medicine.disease medicine.anatomical_structure Neoplasm Micrometastasis Matrix Metalloproteinase 2 Female Bone marrow business Bone Marrow Neoplasms |
| Zdroj: | International journal of molecular medicine. 30(4) |
| ISSN: | 1791-244X |
| Popis: | The presence of cells positive for cytokeratins or prostate-specific antigen (PSA) in bone marrow aspirates (BMAs) has been used to indicate the presence of micrometastasis. The aim of this prospective study of prostate cancer patients was to determine the presence of prostate cells in blood and BMAs and to compare them with bone marrow biopsy touch prep samples. The results indicated that there was a satisfactory concordance between circulating prostate cells (CPCs) in blood and disseminated tumor cells (DTCs) in BMAs for all Gleason scores (κ>0.50). However, neither were concordant with the presence of prostate cells in bone marrow biopsies except for high-grade tumors, Gleason 8 and 9. Phenotypic characteristics of CPCs and DTCs were identical (κ>0.9) but were different than cells detected in bone marrow biopsies (κ |
| Databáze: | OpenAIRE |
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