Multicenter Evaluation of Plasma N-Terminal Probrain Natriuretic Peptide (NT-pro BNP) as a Biochemical Screening Test for Asymptomatic (occult) Cardiomyopathy in Cats
Autor: | N. Sydney Moïse, Karsten E. Schober, John D. Bonagura, Bonnie K. Lefbom, John E. Rush, Clarke E. Atkins, Kristin A. MacDonald, Sonya G. Gordon, Daniel F. Hogan, Teresa C. DeFrancesco, Bruce W. Keene, Caryn A. Reynolds, Rebecca L. Stepien, Thaibinh P. Nguyenba, Philip R. Fox, Linda B. Lehmkuhl, Mark A. Oyama, Heidi B. Kellihan |
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Rok vydání: | 2011 |
Předmět: |
Male
medicine.medical_specialty Pathology medicine.drug_class Cardiomyopathy Doppler echocardiography Cat Diseases Sensitivity and Specificity Asymptomatic Gastroenterology Interquartile range Internal medicine Natriuretic Peptide Brain Natriuretic peptide medicine Animals CATS General Veterinary medicine.diagnostic_test Receiver operating characteristic business.industry medicine.disease Peptide Fragments Case-Control Studies Cats Biomarker (medicine) Female medicine.symptom Cardiomyopathies business Biomarkers |
Zdroj: | Journal of Veterinary Internal Medicine. 25:1010-1016 |
ISSN: | 0891-6640 |
Popis: | B-type natriuretic peptide concentrations reliably distinguish between cardiac and respiratory causes of dyspnea, but its utility to detect asymptomatic cats with occult cardiomyopathy (OCM) is unresolved.Determine whether plasma N terminal probrain natriuretic peptide (NT-proBNP) concentration can discriminate asymptomatic cats with OCM from normal cats, and whether NT-proBNP concentration correlates with clinical, biochemical, and echocardiographic parameters.One hundred and fourteen normal, healthy cats; 113 OCM cats.Prospective, multicenter, case-controlled study. NT-proBNP was prospectively measured and cardiac status was determined from history, physical examination, and M-mode/2D/Doppler echocardiography. Optimal cut-off values were derived using receiver operating characteristic (ROC) curve analysis.NT-proBNP was higher (median, interquartile range [25th and 75th percentiles]) in (1) OCM (186 pmol/L; 79, 478 pmol/L) versus normal (24 pmol/L; 24, 32 pmol/L) (P.001); and (2) hypertrophic obstructive cardiomyopathy (396 pmol/L; 205, 685 pmol/L) versus hypertrophic cardiomyopathy (112 pmol/L; 48, 318 pmol/L) (P.001). In OCM, NT-proBNP correlated (1) positively with LVPWd (ρ = 0.23; P = .01), LA/Ao ratio (ρ = 0.31; P.001), LVs (ρ = 0.33; P.001), and troponin-I (ρ = 0.64; P.001), and (2) negatively with %FS (ρ = -0.27; P = .004). Area under ROC curve was 0.92;46 pmol/L cut-off distinguished normal from OCM (91.2% specificity, 85.8% sensitivity);99 pmol/L cut-off was 100% specific, 70.8% sensitive.Plasma NT-proBNP concentration reliably discriminated normal from OCM cats, and was associated with several echocardiographic markers of disease severity. Further studies are needed to assess test performance in unselected, general feline populations, and evaluate relationships between NT-proBNP concentrations and disease progression. |
Databáze: | OpenAIRE |
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